Western Blot (WB)
(Western blot analysis of TorsinA expression in MCF7 (A), SW480 (B), mouse liver (C) whole cell lysates.)
Rabbit TorsinA Polyclonal Antibody | anti-TOR1A antibody
Anti-TorsinA Antibody
Western Blot (WB)
(Western blot analysis of TorsinA expression in MCF7 (A), SW480 (B), mouse liver (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of TorsinA expression in MCF7 (A), SW480 (B), mouse liver (C) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of TorsinA staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of TorsinA staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]
Uniprot Description
TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: cell junction; cytoplasmic vesicle membrane; cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; growth cone; membrane; nuclear envelope; nuclear membrane; secretory granule; synaptic vesicle
Molecular Function: ATP binding; ATPase activity; cytoskeletal protein binding; kinesin binding; misfolded protein binding; protein binding; unfolded protein binding
Biological Process: cell adhesion; chaperone cofactor-dependent protein folding; intermediate filament cytoskeleton organization and biogenesis; neurite development; nuclear membrane organization and biogenesis; organelle organization and biogenesis; protein deneddylation; protein homooligomerization; regulation of dopamine uptake; response to oxidative stress; synaptic vesicle transport
Disease: Dystonia 1, Torsion, Autosomal Dominant
Research Articles on TOR1A
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Product Notes
The TOR1A tor1a (Catalog #AAA8245638) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TorsinA Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TorsinA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1/500 - 1/2000; IHC: 1/50 - 1/200. Researchers should empirically determine the suitability of the TOR1A tor1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TorsinA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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