Western Blot (WB)
(Western blot analysis of Ryanodine Receptor 2 expression in PC3 (A), MCF7 (B), NIH3T3 (C), mouse brain (D) whole cell lysates.)
Rabbit Ryanodine Receptor 2 Polyclonal Antibody | anti-RYR2 antibody
Anti-Ryanodine Receptor 2 Antibody
Western Blot (WB)
(Western blot analysis of Ryanodine Receptor 2 expression in PC3 (A), MCF7 (B), NIH3T3 (C), mouse brain (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Ryanodine Receptor 2 expression in PC3 (A), MCF7 (B), NIH3T3 (C), mouse brain (D) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
Uniprot Description
RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.
Protein type: Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Transporter; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: cytosol; membrane; plasma membrane; protein complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; Z disc
Molecular Function: calcium channel activity; calcium ion binding; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; identical protein binding; intracellular ligand-gated calcium channel activity; protein binding; protein self-association; ryanodine-sensitive calcium-release channel activity
Biological Process: BMP signaling pathway; calcium ion transport; calcium-mediated signaling; cardiac muscle contraction; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of calcium ion; positive regulation of heart rate; positive regulation of sequestering of calcium ion; regulation of heart rate; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; release of sequestered calcium ion into cytosol; response to caffeine; response to hypoxia; response to muscle activity; response to redox state; transmembrane transport; Wnt receptor signaling pathway through beta-catenin
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 2; Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy
Research Articles on RYR2
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Product Notes
The RYR2 ryr2 (Catalog #AAA8242365) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Ryanodine Receptor 2 Antibody reacts with Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's Ryanodine Receptor 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1/500 - 1/1000. Researchers should empirically determine the suitability of the RYR2 ryr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ryanodine Receptor 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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