KIAA1279 sirna

KIAA1279 siRNA (Human)

Cat. Num. AAA8233540

• Gene Names: KIF1BP; KBP; TTC20; KIAA1279
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: KIAA1279; KIAA1279 siRNA (Human); KBP; KIF1-binding protein; KIAA1279 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: KIAA1279 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 621

• Applicable Applications for KIAA1279 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human KIAA1279 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for KIAA1279 sirna

siRNA to inhibit KIAA1279 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 24308113
• NCBI GeneID: 26128
• NCBI Accession #: NP_056449.1
• NCBI GenBank Nucleotide #: NM_015634.3
• UniProt Accession #: Q96EK5; Q9BR89; Q9ULE1; Q9Y428; A8K5M8
• Molecular Weight: 71,814 Da
• NCBI Official Full Name: KIF1-binding protein
• NCBI Official Synonym Full Names: KIF1 binding protein
• NCBI Official Symbol: KIF1BP
• NCBI Official Synonym Symbols: KBP; TTC20; KIAA1279
• NCBI Protein Information: KIF1-binding protein
• UniProt Protein Name: KIF1-binding protein
• UniProt Gene Name: KIF1BP
• UniProt Entry Name: KBP_HUMAN

NCBI Description

This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome. [provided by RefSeq, Mar 2010]

Uniprot Description

KIF1BP: Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity. Defects in KIAA1279 are the cause of Goldberg-Shprintzen megacolon syndrome (GOSHS). GOSHS is characterized by microcephaly, mental retardation and facial dysmorphism, as well as phenotypes related to Hirschsprung disease syndrome. Belongs to the KIF1-binding protein family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: cytoskeleton; mitochondrion

Molecular Function: protein binding; kinesin binding

Biological Process: nervous system development; cell differentiation; mitochondrial transport

Disease: Goldberg-shprintzen Syndrome