DNAJC3 blocking peptide
DnaJC3 Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Uniprot Description
DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Protein type: Endoplasmic reticulum; Inhibitor; Protein kinase, regulatory subunit; Chaperone
Chromosomal Location of Human Ortholog: 13q32.1
Cellular Component: smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; cytoplasm; vesicle
Molecular Function: protein kinase inhibitor activity; chaperone binding; misfolded protein binding
Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; proteolysis involved in cellular protein catabolic process; unfolded protein response; negative regulation of protein kinase activity; defense response to virus; negative regulation of apoptosis
Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus
Research Articles on DNAJC3
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Product Notes
The DNAJC3 dnajc3 (Catalog #AAA8231349) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The DnaJC3 Blocking Peptide reacts with Human, Mouse, Rat, Bovine, Porcine and may cross-react with other species as described in the data sheet. AAA Biotech's DnaJC3 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Researchers should empirically determine the suitability of the DNAJC3 dnajc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DnaJC3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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