SLC26A7 sirna

SLC26A7 siRNA (Human)

Cat. Num. AAA8225248

• Gene Names: SLC26A7; SUT2
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC26A7; SLC26A7 siRNA (Human); SUT2; Anion exchange transporter; Solute carrier family 26 member 7; SLC26A7 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SLC26A7 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 656

• Applicable Applications for SLC26A7 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLC26A7 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC26A7 sirna

siRNA to inhibit SLC26A7 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 537544571
• NCBI GeneID: 115111
• NCBI Accession #: NP_001269285.1
• NCBI GenBank Nucleotide #: NM_001282356.1
• UniProt Accession #: Q8TE54; Q24JS8; Q8TE53; Q96RN2
• Molecular Weight: 73,033 Da
• NCBI Official Full Name: anion exchange transporter isoform a
• NCBI Official Synonym Full Names: solute carrier family 26 (anion exchanger), member 7
• NCBI Official Symbol: SLC26A7
• NCBI Official Synonym Symbols: SUT2
• NCBI Protein Information: anion exchange transporter
• UniProt Protein Name: Anion exchange transporter
• Protein Family: Anion exchange transporter
• UniProt Gene Name: SLC26A7
• UniProt Entry Name: S26A7_HUMAN

NCBI Description

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]

Uniprot Description

SLC26A7: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: basolateral plasma membrane; recycling endosome membrane; cytoplasm; plasma membrane; integral to membrane; endosome

Molecular Function: bicarbonate transmembrane transporter activity; chloride channel activity; anion:anion antiporter activity; sulfate transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity

Biological Process: gastric acid secretion; bicarbonate transport; sulfate transport; ion transport; chloride transport; oxalate transport; transmembrane transport; anion transport