SLC25A29 sirna

SLC25A29 siRNA (Human)

Cat. Num. AAA8223917

• Gene Names: SLC25A29; CACL; ORNT3; C14orf69
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC25A29; SLC25A29 siRNA (Human); C14orf69; ORNT3; Mitochondrial carnitine/acylcarnitine carrier protein CACL; Carnitine/acylcarnitine translocase-like; CACT-like; Mitochondrial ornithine transporter 3; Solute carrier family 25 member 29; SLC25A29 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SLC25A29 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 303

• Applicable Applications for SLC25A29 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLC25A29 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC25A29 sirna

siRNA to inhibit SLC25A29 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 86198310
• NCBI GeneID: 123096
• NCBI Accession #: NP_001034444.1
• NCBI GenBank Nucleotide #: NM_001039355.2
• UniProt Accession #: Q8N8R3; Q541V0; A3KMR5
• Molecular Weight: 25,051 Da
• NCBI Official Full Name: mitochondrial basic amino acids transporter isoform 1
• NCBI Official Synonym Full Names: solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
• NCBI Official Symbol: SLC25A29
• NCBI Official Synonym Symbols: CACL; ORNT3; C14orf69
• NCBI Protein Information: mitochondrial basic amino acids transporter
• UniProt Protein Name: Mitochondrial basic amino acids transporter
• Protein Family: Mitochondrial basic amino acids transporter
• UniProt Gene Name: SLC25A29
• UniProt Synonym Gene Names: C14orf69; ORNT3; CACT-like
• UniProt Entry Name: MCATL_HUMAN

NCBI Description

This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Description

SLC25A29: Has palmitoylcarnitine transporting activity. Belongs to the mitochondrial carrier family.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Mitochondrial

Chromosomal Location of Human Ortholog: 14q32.2

Cellular Component: mitochondrial inner membrane; integral to membrane

Molecular Function: acyl carnitine transporter activity