Western Blot (WB)
(Western blot analysis of GGT5 HC expression in A549 (A), NS-1 (B), H9C2 (C) whole cell lysates.)
Rabbit GGT5 HC Polyclonal Antibody | anti-GGT5 antibody
Anti-GGT5 HC Antibody
Western Blot (WB)
(Western blot analysis of GGT5 HC expression in A549 (A), NS-1 (B), H9C2 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of GGT5 HC expression in A549 (A), NS-1 (B), H9C2 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Description
GGT5: Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Other Amino Acids Metabolism - cyanoamino acid; EC 3.4.19.14; Membrane protein, integral; Transferase; Other Amino Acids Metabolism - glutathione; EC 3.4.19.13; Other Amino Acids Metabolism - selenoamino acid; EC 2.3.2.2; Other Amino Acids Metabolism - taurine and hypotaurine; Lipid Metabolism - arachidonic acid
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: anchored to external side of plasma membrane; plasma membrane; integral to membrane
Molecular Function: gamma-glutamyltransferase activity
Biological Process: leukotriene biosynthetic process; amino acid metabolic process; glutathione metabolic process; glutathione biosynthetic process; arachidonic acid metabolic process; leukotriene metabolic process; inflammatory response; proteolysis
Research Articles on GGT5
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Product Notes
The GGT5 ggt5 (Catalog #AAA8209628) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GGT5 HC Antibody reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's GGT5 HC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the GGT5 ggt5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GGT5 HC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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