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NEURL1 sirna

NEURL1 siRNA (Human)

Gene Names
NEURL1; neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1
Reactivity
Human
Applications
RNA Interference (RNAi)
Purity
> 97%
Synonyms
NEURL1; NEURL1 siRNA (Human); NEURL; NEURL1A; RNF67; E3 ubiquitin-protein ligase NEURL1; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67; NEURL1 sirna
Ordering
For Research Use Only!
Host
Synthetic
Reactivity
Human
Specificity
NEURL1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Sequence Length
557
Applicable Applications for NEURL1 sirna
RNA Interference (RNAi)
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human NEURL1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Related Product Information for NEURL1 sirna
siRNA to inhibit NEURL1 expression using RNA interference

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
60,030 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase NEURL1
NCBI Official Synonym Full Names
neuralized E3 ubiquitin protein ligase 1
NCBI Official Symbol
NEURL1
NCBI Official Synonym Symbols
neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1
NCBI Protein Information
E3 ubiquitin-protein ligase NEURL1
UniProt Protein Name
E3 ubiquitin-protein ligase NEURL1
UniProt Gene Name
NEURL1
UniProt Synonym Gene Names
NEURL; NEURL1A; RNF67; h-neu; h-neuralized 1
UniProt Entry Name
NEUL1_HUMAN

Uniprot Description

NEURL1: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 6.3.2.-; Cell development/differentiation; Ubiquitin conjugating system; Ligase; Tumor suppressor; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: postsynaptic membrane; perinuclear region of cytoplasm; postsynaptic density; plasma membrane; dendritic spine; perikaryon; cell junction

Molecular Function: translation factor activity, non-nucleic acid binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: lactation; protein monoubiquitination; positive regulation of filopodium formation; nervous system development; Notch signaling pathway; positive regulation of apoptosis; positive regulation of long-term neuronal synaptic plasticity; regulation of translation; negative regulation of cell proliferation; sperm motility; positive regulation of epidermal growth factor receptor activity; sperm axoneme assembly; negative regulation of Notch signaling pathway

Research Articles on NEURL1

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Product Notes

The NEURL1 neurl1 (Catalog #AAA8206795) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The NEURL1 siRNA (Human) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NEURL1 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the NEURL1 neurl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NEURL1, siRNA" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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