UQCC2 sirna

UQCC2 siRNA (Human)

Cat. Num. AAA8206373

• Gene Names: UQCC2; M19; Cbp6; MNF1; C6orf125; bA6B20.2
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: UQCC2; UQCC2 siRNA (Human); C6orf125; MNF1; Ubiquinol-cytochrome-c reductase complex assembly factor 2; Breast cancer-associated protein SGA-81M; Mitochondrial nucleoid factor 1; Mitochondrial protein M19; UQCC2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: UQCC2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 126

• Applicable Applications for UQCC2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human UQCC2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for UQCC2 sirna

siRNA to inhibit UQCC2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 14150128
• NCBI GeneID: 84300
• NCBI Accession #: NP_115716.1
• NCBI GenBank Nucleotide #: NM_032340.3
• UniProt Accession #: Q9BRT2; B2R4I0
• Molecular Weight: 14,875 Da
• NCBI Official Full Name: ubiquinol-cytochrome-c reductase complex assembly factor 2
• NCBI Official Synonym Full Names: ubiquinol-cytochrome c reductase complex assembly factor 2
• NCBI Official Symbol: UQCC2
• NCBI Official Synonym Symbols: M19; Cbp6; MNF1; C6orf125; bA6B20.2
• NCBI Protein Information: ubiquinol-cytochrome-c reductase complex assembly factor 2
• UniProt Protein Name: Ubiquinol-cytochrome-c reductase complex assembly factor 2
• Protein Family: Ubiquinol-cytochrome-c reductase complex assembly factor
• UniProt Gene Name: UQCC2
• UniProt Synonym Gene Names: C6orf125; MNF1
• UniProt Entry Name: UQCC2_HUMAN

NCBI Description

This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]

Uniprot Description

UQCC2: Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane; mitochondrial intermembrane space; nucleus

Molecular Function: protein binding

Biological Process: regulation of oxidative phosphorylation; regulation of insulin secretion

Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 7