CC2D1A sirna

CC2D1A siRNA (Rat)

Cat. Num. AAA8201044

• Gene Names: Cc2d1a; RGD1306108
• Reactivity: Rat
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: CC2D1A; CC2D1A siRNA (Rat); Coiled-coil and C2 domain-containing protein 1A; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; CC2D1A sirna

• Host: Synthetic
• Reactivity: Rat
• Specificity: CC2D1A siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 896

• Applicable Applications for CC2D1A sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat CC2D1A gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for CC2D1A sirna

siRNA to inhibit CC2D1A expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 62078473
• NCBI GeneID: 288908
• NCBI Accession #: NP_001013891.1
• NCBI GenBank Nucleotide #: NM_001013869.1
• UniProt Accession #: Q66HA5
• Molecular Weight: 98,618 Da
• NCBI Official Full Name: coiled-coil and C2 domain-containing protein 1A
• NCBI Official Synonym Full Names: coiled-coil and C2 domain containing 1A
• NCBI Official Symbol: Cc2d1a
• NCBI Official Synonym Symbols: RGD1306108
• NCBI Protein Information: coiled-coil and C2 domain-containing protein 1A
• UniProt Protein Name: Coiled-coil and C2 domain-containing protein 1A
• Protein Family: Coiled-coil and C2 domain-containing protein
• UniProt Gene Name: Cc2d1a
• UniProt Synonym Gene Names: FRE under dual repression-binding protein 1; Freud-1
• UniProt Entry Name: C2D1A_RAT

Uniprot Description

CC2D1A: Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses (By similarity)

Protein type: Transcription factor

Cellular Component: membrane; cytoplasm; nucleus

Molecular Function: signal transducer activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction