Mouse anti-Human FGFR2 Monoclonal Antibody | anti-FGFR2 antibody
Anti-FGFR2 Antibody, Mouse Monoclonal
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
FGFR2; Monoclonal Antibody; Anti-FGFR2 Antibody; Mouse Monoclonal; FGFR2 Antibody; Mouse MAb; Anti-BBDS Antibody; Anti-BEK Antibody; Anti-BFR-1 Antibody; Anti-CD332 Antibody; Anti-CEK3 Antibody; Anti-CFD1 Antibody; Anti-ECT1 Antibody; Anti-JWS Antibody; Anti-K-SAM Antibody; Anti-KGFR Antibody; Anti-TK14 Antibody; Anti-TK25 Antibody; fibroblast growth factor receptor 2; anti-FGFR2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone Number
2
Specificity
Human FGFR2
Purity/Purification
Protein A
Form/Format
Liquid. 0.2um filtered solution in PBS
Applicable Applications for anti-FGFR2 antibody
ELISA (EIA)(Det)
Immunogen
Recombinant Human FGFR2 Protein
Conjugation
Unconjugated
Preparation
This product is a recombinant monoclonal antibody expressed from HEK293 cells.
Notes
ELISA(Det): This antibody will detect Human FGFR2/CD332 in ELISA pair set. In a sandwich ELISA, it can be used as detection antibody when paired with.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Related Product Information for anti-FGFR2 antibody
Background: FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.
Product Categories/Family for anti-FGFR2 antibody
References
Marie PJ, et al. (2003) Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol. 17(3):877-85.
Park WJ, et al. (1996) Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability. Hum Mol Genet. 4(7):1229-33.
Orr-Urtreger A, et al. (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol. 158(2):475-86.
Park WJ, et al. (1996) Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability. Hum Mol Genet. 4(7):1229-33.
Orr-Urtreger A, et al. (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol. 158(2):475-86.
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Product Notes
The FGFR2 (Catalog #AAA8118974) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-FGFR2 Antibody, Mouse Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FGFR2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(Det). Researchers should empirically determine the suitability of the FGFR2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FGFR2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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