Rabbit anti-Mouse PD-L2 Polyclonal Antibody | anti-PDCD1LG2 antibody

Anti-PD-L2 Antibody, Rabbit Polyclonal

Cat. Num. AAA8112088

• Gene Names: Pdcd1lg2; Btdc; B7-DC; PD-L2; F730015O22Rik
• Reactivity: Mouse
• Applications: ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: PD-L2; Polyclonal Antibody; Anti-PD-L2 Antibody; Rabbit Polyclonal; B7-DC/PD-L2/CD273 Antibody; Rabbit PAb; Antigen Affinity Purified; programmed cell death 1 ligand 2; Anti-B7-DC Antibody; Anti-Btdc Antibody; Anti-F730015O22Rik Antibody; anti-PDCD1LG2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse B7-DC/PD-L2/CD273
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-PDCD1LG2 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:5000-1:10,000
• Immunogen: Recombinant Mouse B7-DC/PD-L2/CD273 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse B7-DC/PD-L2/CD273. B7-DC/PD-L2/CD273 specific IgG was purified by Mouse B7-DC/PD-L2/CD273 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PDCD1LG2 antibody

Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

Product Categories/Family for anti-PDCD1LG2 antibody

Cancer Drug Targets

References

Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.

NCBI and Uniprot Product Information

• NCBI GI #: 10946740
• NCBI GeneID: 58205
• NCBI Accession #: NP_067371.1
• NCBI GenBank Nucleotide #: NM_021396.2
• UniProt Accession #: Q9WUL5
• Molecular Weight: 27,820 Da
• NCBI Official Full Name: programmed cell death 1 ligand 2
• NCBI Official Synonym Full Names: programmed cell death 1 ligand 2
• NCBI Official Symbol: Pdcd1lg2
• NCBI Official Synonym Symbols: Btdc; B7-DC; PD-L2; F730015O22Rik
• NCBI Protein Information: programmed cell death 1 ligand 2; PD-1 ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; butyrophilin-like protein; programmed death ligand 2
• UniProt Protein Name: Programmed cell death 1 ligand 2
• Protein Family: Programmed cell death
• UniProt Gene Name: Pdcd1lg2
• UniProt Synonym Gene Names: B7dc; Btdc; Cd273; Pdl2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC
• UniProt Entry Name: PD1L2_MOUSE

Uniprot Description

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of T cell proliferation; negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; positive regulation of T cell proliferation