Immunohistochemistry (IHC)
(Immunochemical staining of mouse PDPN in mouse kidney with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Rabbit anti-Mouse Podoplanin Monoclonal Antibody | anti-PDPN antibody
Recombinant Anti-Podoplanin Antibody, Rabbit Monoclonal
Gene Names
Pdpn; T1a; Gp38; OTS-8; T1alpha; RANDAM-2; T1-alpha
Reactivity
Mouse
Applications
Immunohistochemistry
Purity
Protein A
Synonyms
Podoplanin; Monoclonal Antibody; Recombinant Anti-Podoplanin Antibody; Rabbit Monoclonal; Podoplanin/PDPN Antibody; Rabbit MAb; podoplanin; Anti-Gp38 Antibody; Anti-OTS-8 Antibody; Anti-RANDAM-2 Antibody; Anti-T1-alpha Antibody; Anti-T1a Antibody; Anti-T1alpha Antibody; anti-PDPN antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
066
Specificity
Mouse Podoplanin/PDPN
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-PDPN antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:250-1:1000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse Podoplanin/PDPN Protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Podoplanin/PDPN (rM Podoplanin/PDPN).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of mouse PDPN in mouse kidney with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse PDPN in mouse kidney with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse PDPN in mouse brain with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse PDPN in mouse brain with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-PDPN antibody
Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a marker for epithelioid hemangioendothelioma in liver tumors.
References
Kimura, N. et al., 2005, Pathol Int. 55 (2): 83-86. Ordonez, N.G., 2006, Adv Anat Pathol. 13 (2): 83-88. Wicki, A. et al., 2007, Br. J. Cancer. 96 (1): 1-5. Fujii, T. et al., 2008, Mod Pathol. 21 (2): 125-130. Sawa, Y. et al., 2008, Acta Histochem Cytochem. 41 (5):121-126. Kaddu, S. et al., 2009, Am J Dermatopathol. 31 (2): 137-139.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,233 Da
NCBI Official Full Name
podoplanin
NCBI Official Synonym Full Names
podoplanin
NCBI Official Symbol
Pdpn
NCBI Official Synonym Symbols
T1a; Gp38; OTS-8; T1alpha; RANDAM-2; T1-alpha
NCBI Protein Information
podoplanin; aggrus; PA2.26 antigen; glycoprotein 38; transmembrane glycoprotein E11
UniProt Protein Name
Podoplanin
Protein Family
UniProt Gene Name
Pdpn
UniProt Synonym Gene Names
Gp38; Ots8; Gp38; T1A
Uniprot Description
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
Research Articles on PDPN
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Product Notes
The PDPN pdpn (Catalog #AAA8111274) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-Podoplanin Antibody, Rabbit Monoclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Podoplanin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:250-1:1000. Researchers should empirically determine the suitability of the PDPN pdpn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Podoplanin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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