Rabbit anti-Mouse Surfactant protein D/SFTPD Monoclonal Antibody | anti-SFTPD antibody

Recombinant Anti-Surfactant protein D/SFTPD Antibody, Rabbit Monoclonal

Cat. Num. AAA8111197

• Gene Names: Sftpd; SP-D; Sfpd; Sftp4; AI573415
• Reactivity: Mouse
• Applications: ELISA, ELISA
• Purity: Protein A
• Synonyms: Surfactant protein D/SFTPD; Monoclonal Antibody; Recombinant Anti-Surfactant protein D/SFTPD Antibody; Rabbit Monoclonal; SFTPD/SP-D/SFTP4 Antibody; Rabbit MAb; surfactant protein D; Anti-AI573415 Antibody; Anti-Sftp4 Antibody; Anti-SP-D Antibody; anti-SFTPD antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 19
• Specificity: Mouse SFTPD/PSPD/COLEC7
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SFTPD antibody: ELISA (EIA), ELISA (EIA) (Cap)
• Application Notes: ELISA: 1:5000-1:10,000; ELISA (Cap): 1:250-1:2000; ELISA (Cap): This antibody will detect Mouse SFTPD/SP-D in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody.
• Antibody Type: Recombinant Antibody
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SFTPD (rM SFTPD).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SFTPD antibody

Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides, it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

References

Leth-Larsen R, et al. (2005) A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol. 174(3): 1532-8.Moran AP, et al. (2005) Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide. J Endotoxin Res. 11(6): 357-62.Hartl D, et al. (2006) Surfactant protein D in human lung diseases. Eur J Clin Invest. 36(6): 423-35.Krueger M, et al. (2006) Amino acid variants in Surfactant protein D are not associated with bronchial asthma. Pediatr Allergy Immunol. 17(1): 77-81.Glas J, et al. (2008) Increased plasma concentration of surfactant protein D in chronic periodontitis independent of SFTPD genotype: potential role as a biomarker. Tissue Antigens. 72(1): 21-8.

NCBI and Uniprot Product Information

• NCBI GI #: 6677921
• NCBI GeneID: 20390
• NCBI Accession #: NP_033186.1
• NCBI GenBank Nucleotide #: NM_009160.2
• UniProt Accession #: P50404
• Molecular Weight: 37,688 Da
• NCBI Official Full Name: pulmonary surfactant-associated protein D
• NCBI Official Synonym Full Names: surfactant associated protein D
• NCBI Official Symbol: Sftpd
• NCBI Official Synonym Symbols: SP-D; Sfpd; Sftp4; AI573415
• NCBI Protein Information: pulmonary surfactant-associated protein D
• UniProt Protein Name: Pulmonary surfactant-associated protein D
• Protein Family: Pulmonary surfactant-associated protein
• UniProt Gene Name: Sftpd
• UniProt Synonym Gene Names: Sftp4; PSP-D; SP-D
• UniProt Entry Name: SFTPD_MOUSE

Uniprot Description

SFTPD: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Belongs to the SFTPD family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: multivesicular body; proteinaceous extracellular matrix; extracellular space; collagen; rough endoplasmic reticulum; cytoplasm; extracellular region; cytoplasmic vesicle

Molecular Function: monosaccharide binding; identical protein binding; lipopolysaccharide binding; carbohydrate binding

Biological Process: negative regulation of phagocytosis; negative regulation of T cell proliferation; immune system process; positive regulation of phagocytosis; innate immune response; opsonization; respiratory gaseous exchange; regulation of liquid surface tension; surfactant homeostasis; alveolus development; negative regulation of interleukin-2 production