Rabbit anti-Human Adenylate Kinase 1 Polyclonal Antibody | anti-AK1 antibody

Anti-Adenylate Kinase 1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8106444

• Gene Names: AK1; HTL-S-58j
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: Adenylate Kinase 1; Polyclonal Antibody; Anti-Adenylate Kinase 1 Antibody; Rabbit Polyclonal; AK1/Adenylate kinase 1 Antibody; Rabbit PAb; adenylate kinase 1; Anti-HTL-S-58j Antibody; anti-AK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human AK1/Adenylate kinase 1
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-AK1 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human AK1/Adenylate kinase 1 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human AK1/Adenylate kinase 1 (rh AK1). Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-AK1 antibody

The adenylate kinase (AK) isoforms network plays an important role in the intracellular energy transfer processes, the maintenance of energy homeostasis, and it is a major player in AMP metabolic signaling circuits in some highly-differentiated cells. Three other biomarkers (AK1, CLIC1, and SOD1) were significantly increased in both adenoma and early colorectal cancer patient plasma samples and in plasma from colorectal cancer mouse models at preclinical stages compared with controls.Which can contribute to the detection of early-stage colorectal cancer and adenomas.

References

Lu Q, et al. (1996) Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism. Proc Natl Acad Sci. 93 (12): 5720-5.Dzeja P, et al. (2009) Adenylate kinase and AMP signaling networks: Metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci. 10 (4): 1729-72.Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.

NCBI and Uniprot Product Information

• NCBI GI #: 12654563
• NCBI GeneID: 203
• Molecular Weight: 21,635 Da
• NCBI Official Full Name: Adenylate kinase 1
• NCBI Official Synonym Full Names: adenylate kinase 1
• NCBI Official Symbol: AK1
• NCBI Official Synonym Symbols: HTL-S-58j
• NCBI Protein Information: adenylate kinase isoenzyme 1
• Protein Family: Adenylate kinase

NCBI Description

This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]