Mouse anti-Human Pentraxin 3 Monoclonal Antibody | anti-PTX3 antibody

Anti-Pentraxin 3 Antibody, Mouse Monoclonal

Cat. Num. AAA8106160

• Gene Names: PTX3; TSG-14; TNFAIP5
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: Pentraxin 3; Monoclonal Antibody; Anti-Pentraxin 3 Antibody; Mouse Monoclonal; PTX3/Pentraxin 3/TSG-14 Antibody; Mouse MAb; pentraxin 3; Anti-PTX3 Antibody; Anti-TNFAIP5 Antibody; Anti-TSG-14 Antibody; anti-PTX3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 03
• Specificity: Human PTX3/Pentraxin 3/TSG-14
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-PTX3 antibody: ELISA (EIA) (Cap)
• Application Notes: ELISA (Cap): This antibody will detect Human PTX3/Pentraxin 3/TSG-14 in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody.
• Immunogen: Recombinant Human PTX3/Pentraxin 3/TSG-14 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PTX3/Pentraxin 3/TSG-14 (rh PTX3/Pentraxin 3/TSG-14). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PTX3 antibody

Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

References

Rolph, M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4. Mantovani A., et al., 2003, Vaccine. 21:S43-S47. Luchetti, M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72. Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30. Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.

NCBI and Uniprot Product Information

• NCBI GI #: 167900484
• NCBI GeneID: 5806
• NCBI Accession #: NP_002843.2
• NCBI GenBank Nucleotide #: NM_002852.3
• UniProt Accession #: P26022; Q38M82; B2R6T6
• Molecular Weight: 41,976 Da
• NCBI Official Full Name: pentraxin-related protein PTX3
• NCBI Official Synonym Full Names: pentraxin 3, long
• NCBI Official Symbol: PTX3
• NCBI Official Synonym Symbols: TSG-14; TNFAIP5
• NCBI Protein Information: pentraxin-related protein PTX3; pentraxin-3; TNF alpha-induced protein 5; pentaxin-related protein PTX3; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor, alpha-induced protein 5; tumor necrosis factor-inducible protein TSG-14; tumor n
• UniProt Protein Name: Pentraxin-related protein PTX3
• Protein Family: Pentraxin-related protein
• UniProt Gene Name: PTX3
• UniProt Synonym Gene Names: TNFAIP5; TSG14; TNF alpha-induced protein 5; TSG-14
• UniProt Entry Name: PTX3_HUMAN

Uniprot Description

PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q25

Cellular Component: extracellular space; extracellular region

Molecular Function: complement component C1q binding; zymosan binding; virion binding

Biological Process: positive regulation of nitric oxide biosynthetic process; negative regulation of virion penetration into host cell; positive regulation of phagocytosis; innate immune response; response to yeast; opsonization; inflammatory response