Rabbit anti-Human VWC2 Polyclonal Antibody | anti-VWC2 antibody
Anti-VWC2 Antibody, Rabbit Polyclonal
Gene Names
VWC2; UNQ739; PSST739
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
VWC2; Polyclonal Antibody; Anti-VWC2 Antibody; Rabbit Polyclonal; VWC2 Antibody; Rabbit PAb; von Willebrand factor C domain containing 2; Anti-PSST739 Antibody; Anti-UNQ739 Antibody; anti-VWC2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human VWC2
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-VWC2 antibody
ELISA (EIA)
Application Notes
ELISA: 1:1000-1:2000
Immunogen
Recombinant Human VWC2 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human VWC2 (rh VWC2). Total IgG was purified by Protein A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-VWC2 antibody
Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein that contains two VWFC domains. VWC2/Brorin is a BMP antagonist that may play a role in neural development. It promotes cell adhesion. VWC2/Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2/Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2/Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.
References
Koike, N. et al., 2007, J Biol Chem. 282 (21):15843-50. Elis, S. et al., 2009, Mol Reprod Dev. 76 (11):1043-55. Zhang, J.L. et al., 2010, PLoS One. 5 (9):e12846.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
35,282 Da
NCBI Official Full Name
brorin
NCBI Official Synonym Full Names
von Willebrand factor C domain containing 2
NCBI Official Symbol
VWC2
NCBI Official Synonym Symbols
UNQ739; PSST739
NCBI Protein Information
brorin; brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2
UniProt Protein Name
Brorin
Protein Family
UniProt Gene Name
VWC2
UniProt Entry Name
VWC2_HUMAN
Uniprot Description
PSST739: BMP antagonist which may play a role in neural development. Promotes cell adhesion.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component: extracellular space; basement membrane; synapse; cell junction
Biological Process: positive regulation of neuron differentiation; negative regulation of BMP signaling pathway
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Product Notes
The VWC2 vwc2 (Catalog #AAA8106138) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-VWC2 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VWC2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000-1:2000. Researchers should empirically determine the suitability of the VWC2 vwc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VWC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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