Rabbit anti-Human OSMR Monoclonal Antibody | anti-OSMR antibody

Recombinant Anti-OSMR Antibody, Rabbit Monoclonal

Cat. Num. AAA8105106

• Gene Names: OSMR; OSMRB; PLCA1; IL-31RB; IL-31R-beta
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay
• Purity: Protein A
• Synonyms: OSMR; Monoclonal Antibody; Recombinant Anti-OSMR Antibody; Rabbit Monoclonal; OSMR/IL-31RB Antibody; Rabbit MAb; oncostatin M receptor; Anti-IL-31RB Antibody; Anti-OSMRB Antibody; Anti-PLCA1 Antibody; anti-OSMR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 002
• Specificity: Human OSMR/IL-31RB
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-OSMR antibody: ELISA (EIA) (Cap), Flow Cytometry (FC/FACS/FCM)
• Application Notes: FC/FACS/FCM: 1:25-1:100; ELISA (Cap): 1:250-1:2000; ELISA (Cap): This antibody will detect Human OSMR/IL-31RB in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody when paired with.
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human OSMR/IL-31RB protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human OSMR/IL-31RB (rh OSMR/IL-31RB).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of Human OSMR expression on HeLa cells. Cells were stained with purified anti-Human OSMR, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.)

Related Product Information for anti-OSMR antibody

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis of familial cutaneous lichen amyloidosis. PLCA1 is hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

References

Arita K, et al.. (2008) Oncostatin M Receptor-beta Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis. Am J Hum. Genet. 82 (1): 73-80.Malaval L, et al.. (2005) GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors. J Cell Physiol. 204(2): 585-93.Lin MW, et al.. (2010) Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 18(1): 26-32.

NCBI and Uniprot Product Information

• NCBI GI #: 4557040
• NCBI GeneID: 9180
• NCBI Accession #: NP_003990.1
• NCBI GenBank Nucleotide #: NM_003999.2
• NCBI Official Full Name: oncostatin-M-specific receptor subunit beta isoform 1
• NCBI Official Synonym Full Names: oncostatin M receptor
• NCBI Official Symbol: OSMR
• NCBI Official Synonym Symbols: OSMRB; PLCA1; IL-31RB; IL-31R-beta
• NCBI Protein Information: oncostatin-M-specific receptor subunit beta
• Protein Family: Oncostatin-M-specific receptor

NCBI Description

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]