Rabbit anti-Human SerpinA3 Monoclonal Antibody | anti-SerpinA3 antibody
Recombinant Anti-SerpinA3 Antibody, Rabbit Monoclonal
Gene Names
SERPINA3; ACT; AACT; GIG24; GIG25
Reactivity
Human
Applications
ELISA, ELISA
Purity
Protein A
Synonyms
SerpinA3; Monoclonal Antibody; Recombinant Anti-SerpinA3 Antibody; Rabbit Monoclonal; SerpinA3 Antibody; Rabbit MAb; serpin peptidase inhibitor; clade A (alpha-1 antiproteinase; antitrypsin); member 3; Anti-AACT Antibody; Anti-ACT Antibody; Anti-GIG24 Antibody; Anti-GIG25 Antibody; Anti-MGC88254 Antibody; Anti-SERPINA3 Antibody; anti-SerpinA3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
006
Specificity
Human SerpinA3.
No cross-reactivity in ELISA with Human SerpinA7, Human SerpinA5, Human SerpinC1, Human SerpinD1, Human SerpinF2
No cross-reactivity in ELISA with Human SerpinA7, Human SerpinA5, Human SerpinC1, Human SerpinD1, Human SerpinF2
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-SerpinA3 antibody
ELISA (EIA), ELISA (EIA) (Det)
Application Notes
ELISA: 1:5000-1:10,000
ELISA (Det): 1:1000-1:10,000
ELISA (Det): This antibody will detect Human SerpinA3 in ELISA pair set.
In a sandwich ELISA, it can be used as detection antibody when paired with.
ELISA (Det): 1:1000-1:10,000
ELISA (Det): This antibody will detect Human SerpinA3 in ELISA pair set.
In a sandwich ELISA, it can be used as detection antibody when paired with.
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human SerpinA3 Protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA3 (rh SerpinA3).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-SerpinA3 antibody
SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. Besides, ACT gene polymorphism has been implicated with Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.
References
Nilsson, L.N. et al., 2001, J. Neurosci. 21: 1444-1451. Ikari, Y. et al., 2001, J. Biol. Chem. 276: 11798-11803. Vila, N. et al., 2000, Stroke. 31: 2103-2105 Eriksson, S. et al., 1995, Proc. Natl. Acad. Sci. USA. 92: 2313-2317. Skeel, A. et al., 2001, J. Biol. Chem. 276: 21932-21937.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
64,000
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Official Symbol
SERPINA3
NCBI Official Synonym Symbols
ACT; AACT; GIG24; GIG25
NCBI Protein Information
alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
UniProt Protein Name
Alpha-1-antichymotrypsin
Protein Family
UniProt Gene Name
SERPINA3
UniProt Synonym Gene Names
AACT; ACT
UniProt Entry Name
AACT_HUMAN
NCBI Description
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Uniprot Description
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular space; extracellular region; intracellular; nucleus
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding
Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
Research Articles on SerpinA3
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Product Notes
The SerpinA3 serpina3 (Catalog #AAA8102206) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-SerpinA3 Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SerpinA3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), ELISA (EIA) (Det). ELISA: 1:5000-1:10,000 ELISA (Det): 1:1000-1:10,000 ELISA (Det): This antibody will detect Human SerpinA3 in ELISA pair set. In a sandwich ELISA, it can be used as detection antibody when paired with. Researchers should empirically determine the suitability of the SerpinA3 serpina3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SerpinA3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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