Rabbit anti-Human Factor XI Monoclonal Antibody | anti-F11 antibody

Recombinant Anti-Factor XI Antibody, Rabbit Monoclonal

Cat. Num. AAA8102181

• Gene Names: F11; FXI
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: Factor XI; Monoclonal Antibody; Recombinant Anti-Factor XI Antibody; Rabbit Monoclonal; Coagulation Factor XI/F11 Antibody; Rabbit MAb; coagulation factor XI; Anti-coagulation factor 11 Antibody; Anti-coagulation factor XI Antibody; Anti-FXI Antibody; anti-F11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 006
• Specificity: Human Coagulation Factor XI/F11
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-F11 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:5000-1:10,000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human Coagulation Factor XI/F11 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor XI/F11 (rh Coagulation Factor XI/F11).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-F11 antibody

Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.

Product Categories/Family for anti-F11 antibody

Serine Proteases and Regulators

References

Gailani D, et al. (2009) Structural and functional features of factor XI. J Thromb Haemost. 7 Suppl 1: 75-8.Duga S, et al. (2009) Factor XI Deficiency. Semin Thromb Hemost. 35(4): 416-25.Emsley J, et al. (2010) Structure and function of factor XI. Blood. 115(13): 2569-77.

NCBI and Uniprot Product Information

• NCBI GI #: 4503627
• NCBI GeneID: 2160
• NCBI Accession #: NP_000119.1
• NCBI GenBank Nucleotide #: NM_000128.3
• UniProt Accession #: P03951; Q4W5C2; Q9Y495; D3DP64
• Molecular Weight: 160,000
• NCBI Official Full Name: coagulation factor XI
• NCBI Official Synonym Full Names: coagulation factor XI
• NCBI Official Symbol: F11
• NCBI Official Synonym Symbols: FXI
• NCBI Protein Information: coagulation factor XI; PTA; plasma thromboplastin antecedent
• UniProt Protein Name: Coagulation factor XI
• Protein Family: Factor XIIa inhibitor
• UniProt Gene Name: F11
• UniProt Synonym Gene Names: FXI; PTA
• UniProt Entry Name: FA11_HUMAN

NCBI Description

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Uniprot Description

F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.27; Protease

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: extracellular space; membrane; plasma membrane; extracellular region

Molecular Function: heparin binding; protein binding; serine-type endopeptidase activity

Biological Process: positive regulation of fibrinolysis; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation

Disease: Factor Xi Deficiency