Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of mGluR5 Glutamate Receptor protein using Mouse Anti-mGluR5 Glutamate Receptor Monoclonal Antibody, Clone S75-33. Primary Antibody: Mouse Anti-mGluR5 Glutamate Receptor Monoclonal Antibody at 1:1000.)
Mouse mGluR1/5 Monoclonal Antibody | anti-Grm5 antibody
mGluR1/5 Antibody: ATTO 390
Gene Names
Grm5; mGluR5; mGlur5
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Synonyms
mGluR1/5; Monoclonal Antibody; mGluR1/5 Antibody: ATTO 390; Glutamate receptor metabotropic 5;GPRC1E; GRM 5; GRM5; Metabotropic glutamate receptor 5; Metabotropic glutamate receptor 5 variant F; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate receptor 5 variant H; mGlu5; mGluR5; mGluR5a; anti-Grm5 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S75-33
Form/Format
Protein G Purified
Concentration
1mg/mL (varies by lot)
Sequence Length
1171
Applicable Applications for anti-Grm5 antibody
Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes
1ug/mL (WB), 0.1-1ug/mL (IHC)
Conjugate
ATTO 390
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of mGluR5 Glutamate Receptor protein using Mouse Anti-mGluR5 Glutamate Receptor Monoclonal Antibody, Clone S75-33. Primary Antibody: Mouse Anti-mGluR5 Glutamate Receptor Monoclonal Antibody at 1:1000.)
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of mGluR5 Glutamate Receptor protein using Mouse Anti-mGluR5 Glutamate Receptor Monoclonal Antibody, Clone S75-33. Primary Antibody: Mouse Anti-mGluR5 Glutamate Receptor Monoclonal Antibody at 1:1000.)
Related Product Information for anti-Grm5 antibody
Background Info: Detects ~130kDa (both mGluR1 and mGluR5)
Scientific Background: The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (3, 4).
Scientific Background: The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (3, 4).
Product Categories/Family for anti-Grm5 antibody
References
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA 2. www.ionchannels.org 3. Mayer M.L. (2005) Current Opinion in Neurobio. 15(3): 282-288. 4. Keinane K., et al. (1990) Science. 249: 556-560.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
128,290 Da
NCBI Official Full Name
metabotropic glutamate receptor 5
NCBI Official Synonym Full Names
glutamate receptor, metabotropic 5
NCBI Official Symbol
Grm5
NCBI Official Synonym Symbols
mGluR5; mGlur5
NCBI Protein Information
metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor (mGluR5)
UniProt Protein Name
Metabotropic glutamate receptor 5
Protein Family
UniProt Gene Name
Grm5
UniProt Synonym Gene Names
Gprc1e; Mglur5; mGluR5
UniProt Entry Name
GRM5_RAT
NCBI Description
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor [RGD, Feb 2006]
Uniprot Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Research Articles on Grm5
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Product Notes
The Grm5 grm5 (Catalog #AAA800532) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The mGluR1/5 Antibody: ATTO 390 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's mGluR1/5 can be used in a range of immunoassay formats including, but not limited to, Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP). 1ug/mL (WB), 0.1-1ug/mL (IHC). Researchers should empirically determine the suitability of the Grm5 grm5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "mGluR1/5, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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