Rabbit GGPS1 Polyclonal Antibody | anti-GGPS1 antibody

GGPS1 Rabbit Polyclonal

Cat. Num. AAA769677

• Gene Names: GGPS1; GGPPS; GGPPS1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GGPS1; Polyclonal Antibody; GGPS1 Rabbit Polyclonal; anti-GGPS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 300

• Applicable Applications for anti-GGPS1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Geranylgeranyl diphosphate synthase 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS769677 (GGPS1 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS769677 (GGPS1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 83700220
• NCBI GeneID: 9453
• NCBI Accession #: NP_001032354.1
• NCBI GenBank Nucleotide #: NM_001037277.1
• Molecular Weight: 28,423 Da
• NCBI Official Full Name: geranylgeranyl pyrophosphate synthase
• NCBI Official Synonym Full Names: geranylgeranyl diphosphate synthase 1
• NCBI Official Symbol: GGPS1
• NCBI Official Synonym Symbols: GGPPS; GGPPS1
• NCBI Protein Information: geranylgeranyl pyrophosphate synthase
• UniProt Protein Name: Geranylgeranyl pyrophosphate synthase
• UniProt Gene Name: GGPS1
• UniProt Synonym Gene Names: GGPP synthase; GGPPSase
• UniProt Entry Name: GGPPS_HUMAN

NCBI Description

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family.

Protein type: EC 2.5.1.10; Motility/polarity/chemotaxis; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.1; EC 2.5.1.29

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytosol

Molecular Function: dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; protein binding

Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; geranylgeranyl diphosphate biosynthetic process; isoprenoid metabolic process