Rabbit CPEB1 Polyclonal Antibody | anti-CPEB1 antibody

CPEB1 Rabbit Polyclonal

Cat. Num. AAA768149

• Gene Names: CPEB1; CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CPEB1; Polyclonal Antibody; CPEB1 Rabbit Polyclonal; anti-CPEB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 335

• Applicable Applications for anti-CPEB1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Cytoplasmic polyadenylation element binding protein 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using MBS768149 (CPEB1 Antibody) at dilution of 1:50)

Western Blot (WB)

(A375 cells were subjected to SDS PAGE followed by western blot with MBS768149 (CPEB1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 572153098
• NCBI GeneID: 64506
• NCBI Accession #: NP_001275749.1
• NCBI GenBank Nucleotide #: NM_001288820.1
• Molecular Weight: 53,635 Da
• NCBI Official Full Name: cytoplasmic polyadenylation element-binding protein 1 isoform 4
• NCBI Official Synonym Full Names: cytoplasmic polyadenylation element binding protein 1
• NCBI Official Symbol: CPEB1
• NCBI Official Synonym Symbols: CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1
• NCBI Protein Information: cytoplasmic polyadenylation element-binding protein 1
• UniProt Protein Name: Cytoplasmic polyadenylation element-binding protein 1
• UniProt Gene Name: CPEB1
• UniProt Synonym Gene Names: CPEB; CPE-BP1; CPE-binding protein 1; h-CPEB; hCPEB-1
• UniProt Entry Name: CPEB1_HUMAN

NCBI Description

This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

CPEB: cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 15q25.2

Cellular Component: cell junction; cell soma; centrosome; cytoplasm; dendrite; growth cone; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic density; postsynaptic membrane; synapse

Molecular Function: metal ion binding; mRNA 3'-UTR binding; nucleotide binding; ribosome binding; translation factor activity, nucleic acid binding; translation repressor activity, nucleic acid binding

Biological Process: cellular response to insulin stimulus; mRNA processing; mRNA transport; negative regulation of cell proliferation; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of translation; translation