Rabbit Prostaglandin Endoperoxide Synthase 1 ELISA Kit | PTGS1 elisa kit

Rabbit Prostaglandin Endoperoxide Synthase 1 ELISA Kit

Cat. Num. AAA763409

• Gene Names: PTGS1; COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
• Reactivity: Rabbit
• Synonyms: Prostaglandin Endoperoxide Synthase 1; Rabbit Prostaglandin Endoperoxide Synthase 1 ELISA Kit; PTGS1 elisa kit

• Reactivity: Rabbit
• Sequence Length: 599

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 0.625-40ng/ml
• Sensitivity: 0.375ng/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Standard Curve

NCBI and Uniprot Product Information

• NCBI GI #: 17017287
• NCBI GeneID: 5742
• Molecular Weight: 72,010 Da
• NCBI Official Full Name: prostaglandin-endoperoxide synthase 1
• NCBI Official Synonym Full Names: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
• NCBI Official Symbol: PTGS1
• NCBI Official Synonym Symbols: COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
• NCBI Protein Information: prostaglandin G/H synthase 1
• UniProt Protein Name: Prostaglandin G/H synthase 1
• Protein Family: Prostaglandin G/H synthase
• UniProt Gene Name: PTGS1
• UniProt Synonym Gene Names: COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1
• UniProt Entry Name: PGH1_HUMAN

NCBI Description

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.99.1

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: cytoplasm; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; nuclear envelope; nucleus; photoreceptor outer segment

Molecular Function: dioxygenase activity; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity

Biological Process: aging; arachidonic acid metabolic process; cyclooxygenase pathway; inflammatory response; learning; lipid metabolic process; memory; negative regulation of epinephrine secretion; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction; prostaglandin biosynthetic process; regulation of blood pressure; regulation of cell proliferation; response to corticosterone stimulus; response to organic nitrogen; response to oxidative stress; sensory perception of pain; xenobiotic metabolic process