Rabbit anti-Human WSB1 Polyclonal Antibody | anti-WSB1 antibody

WSB1 Rabbit Polyclonal

Cat. Num. AAA7605759

• Gene Names: WSB1; SWIP1; WSB-1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: WSB1; Polyclonal Antibody; WSB1 Rabbit Polyclonal; anti-WSB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 421

• Applicable Applications for anti-WSB1 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Immunogen: WD repeat and SOCS box-containing 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7605759 (WSB1 antibody) at dilution of 1:50)

Western Blot (WB)

(SGC-7901 cells were subjected to SDS PAGE followed by western blot with MBS7605759 (WSB1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 7145106
• NCBI GeneID: 26118
• Molecular Weight: 24,724 Da
• NCBI Official Full Name: WSB1 protein
• NCBI Official Synonym Full Names: WD repeat and SOCS box containing 1
• NCBI Official Symbol: WSB1
• NCBI Official Synonym Symbols: SWIP1; WSB-1
• NCBI Protein Information: WD repeat and SOCS box-containing protein 1
• UniProt Protein Name: WD repeat and SOCS box-containing protein 1
• Protein Family: WD repeat and SOCS box-containing protein
• UniProt Gene Name: WSB1
• UniProt Synonym Gene Names: SWIP1; WSB-1
• UniProt Entry Name: WSB1_HUMAN

NCBI Description

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

WSB1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11.1

Cellular Component: cytosol; intracellular

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: protein polyubiquitination