Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas tissue slide using MBS7605742 (WFS1 Antibody) at dilution of 1:200)
Rabbit anti-Human, Mouse WFS1 Polyclonal Antibody | anti-WFS1 antibody
WFS1 Rabbit Polyclonal
Purification Method: Immunogen Affinity Purified
Purification Method: Immunogen Affinity Purified
IHC: 1:50-1:500
IF: 1:50-1:200
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas tissue slide using MBS7605742 (WFS1 Antibody) at dilution of 1:200)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas tissue slide using MBS7605742 (WFS1 Antibody) at dilution of 1:200)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605742 (WFS1 Antibody) at dilution of 1:600)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605742 (WFS1 Antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
WFS1: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4p16.1
Cellular Component: dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; proteasome complex
Molecular Function: ATPase binding; protein binding; transcription activator binding; ubiquitin protein ligase binding
Biological Process: calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; ER overload response; ER-associated protein catabolic process; glucose homeostasis; kidney development; negative regulation of neuron apoptosis; negative regulation of programmed cell death; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; neurological system process; positive regulation of adenylate cyclase activity; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; protein maturation via protein folding; protein stabilization; renal water homeostasis; sensory perception of sound; visual perception
Disease: Cataract 41; Deafness, Autosomal Dominant 6; Diabetes Mellitus, Noninsulin-dependent; Wolfram Syndrome 1; Wolfram-like Syndrome, Autosomal Dominant
Research Articles on WFS1
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Product Notes
The WFS1 wfs1 (Catalog #AAA7605742) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WFS1 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's WFS1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Immunofluoresence (IF). WB: 1:200-1:2000 IHC: 1:50-1:500 IF: 1:50-1:200. Researchers should empirically determine the suitability of the WFS1 wfs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WFS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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