Rabbit anti-Human, Mouse UROC1 Polyclonal Antibody | anti-UROC1 antibody

UROC1 Rabbit Polyclonal

Cat. Num. AAA7605523

• Gene Names: UROC1; UROCD; HMFN0320
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: UROC1; Polyclonal Antibody; UROC1 Rabbit Polyclonal; anti-UROC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 676

• Applicable Applications for anti-UROC1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Urocanase domain containing 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7605523 (UROC1 Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 21389467
• NCBI GeneID: 131669
• NCBI Accession #: NP_653240.1
• NCBI GenBank Nucleotide #: NM_144639.2
• Molecular Weight: 80,912 Da
• NCBI Official Full Name: urocanate hydratase isoform 1
• NCBI Official Synonym Full Names: urocanate hydratase 1
• NCBI Official Symbol: UROC1
• NCBI Official Synonym Symbols: UROCD; HMFN0320
• NCBI Protein Information: urocanate hydratase
• UniProt Protein Name: Urocanate hydratase
• UniProt Gene Name: UROC1
• UniProt Synonym Gene Names: Urocanase
• UniProt Entry Name: HUTU_HUMAN

NCBI Description

This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat. Deficiency of this gene product in the liver is an apparent cause of mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Description

UROC1: Defects in UROC1 are a cause of urocanase deficiency (UROD). An inborn error of histidine metabolism resulting in urocanic aciduria and neurological manifestations including mental retardation, ataxia, episodic aggressive behavior or exaggerated affection-seeking. Belongs to the urocanase family.

Protein type: EC 4.2.1.49; Lyase; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytosol

Molecular Function: urocanate hydratase activity

Biological Process: histidine catabolic process; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate

Disease: Urocanase Deficiency