Rabbit TNNI1 Polyclonal Antibody | anti-TNNI1 antibody

TNNI1 Rabbit Polyclonal

Cat. Num. AAA7605071

• Gene Names: TNNI1; TNN1; SSTNI
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TNNI1; Polyclonal Antibody; TNNI1 Rabbit Polyclonal; anti-TNNI1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 187

• Applicable Applications for anti-TNNI1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Troponin I type 1 (skeletal, slow)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle using MBS7605071 (TNNI1 antibody) at dilution of 1:50)

Western Blot (WB)

(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7605071 (TNNI1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 56682969
• NCBI GeneID: 7135
• NCBI Accession #: NP_003272.3
• NCBI GenBank Nucleotide #: NM_003281.3
• Molecular Weight: 21,692 Da
• NCBI Official Full Name: troponin I, slow skeletal muscle
• NCBI Official Synonym Full Names: troponin I1, slow skeletal type
• NCBI Official Symbol: TNNI1
• NCBI Official Synonym Symbols: TNN1; SSTNI
• NCBI Protein Information: troponin I, slow skeletal muscle
• UniProt Protein Name: Troponin I, slow skeletal muscle
• Protein Family: Troponin
• UniProt Gene Name: TNNI1
• UniProt Entry Name: TNNI1_HUMAN

NCBI Description

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]

Uniprot Description

TNNI1: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q31.3

Cellular Component: cytosol; troponin complex

Molecular Function: actin binding; metal ion binding; protein binding

Biological Process: cardiac muscle contraction; muscle filament sliding; regulation of striated muscle contraction; skeletal muscle contraction; transition between fast and slow fiber; ventricular cardiac muscle morphogenesis