Rabbit RBP3 Polyclonal Antibody | anti-RBP3 antibody

RBP3 Rabbit Polyclonal

Cat. Num. AAA7603423

• Gene Names: RBP3; IRBP; RBPI; RP66; D10S64; D10S65; D10S66
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RBP3; Polyclonal Antibody; RBP3 Rabbit Polyclonal; anti-RBP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1247

• Applicable Applications for anti-RBP3 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Immunogen: Retinol binding protein 3, interstitial
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human eye using MBS7603423 (RBP3 antibody) at dilution of 1:50)

Western Blot (WB)

(mouse eye tissue were subjected to SDS PAGE followed by western blot with MBS7603423 (RBP3 Antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 4506453
• NCBI GeneID: 5949
• NCBI Accession #: NP_002891.1
• NCBI GenBank Nucleotide #: NM_002900.2
• Molecular Weight: 135,363 Da
• NCBI Official Full Name: retinol-binding protein 3
• NCBI Official Synonym Full Names: retinol binding protein 3
• NCBI Official Symbol: RBP3
• NCBI Official Synonym Symbols: IRBP; RBPI; RP66; D10S64; D10S65; D10S66
• NCBI Protein Information: retinol-binding protein 3
• UniProt Protein Name: Retinol-binding protein 3
• Protein Family: Retinol-binding protein
• UniProt Gene Name: RBP3
• UniProt Synonym Gene Names: IRBP
• UniProt Entry Name: RET3_HUMAN

NCBI Description

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]

Uniprot Description

RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular region; extracellular space

Molecular Function: retinal binding; retinoid binding; retinol binding; serine-type peptidase activity

Biological Process: lipid metabolic process; proteolysis; retinoid metabolic process; transport; visual perception

Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 66