Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lymphoma using MBS7603169 (PTPN22 antibody) at dilution of 1:50)
Rabbit PTPN22 Polyclonal Antibody | anti-PTPN22 antibody
PTPN22 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lymphoma using MBS7603169 (PTPN22 antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lymphoma using MBS7603169 (PTPN22 antibody) at dilution of 1:50)
Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7603169 (PTPN22 antibody) at dilution of 1:600)
Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7603169 (PTPN22 antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Uniprot Description
PTPN22: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: cytoplasm; internal side of plasma membrane; nucleus; perinuclear region of cytoplasm
Molecular Function: kinase binding; phosphoric monoester hydrolase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding; ubiquitin protein ligase binding
Biological Process: autophagy; lipopolysaccharide-mediated signaling pathway; negative regulation of autophagy; negative regulation of JNK activity; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of interferon type I production; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; protein amino acid dephosphorylation; regulation of B cell receptor signaling pathway; regulation of innate immune response; regulation of natural killer cell proliferation; response to lipopolysaccharide; T cell differentiation
Disease: Diabetes Mellitus, Insulin-dependent; Rheumatoid Arthritis; Systemic Lupus Erythematosus
Research Articles on PTPN22
Similar Products
Product Notes
The PTPN22 ptpn22 (Catalog #AAA7603169) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPN22 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTPN22 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the PTPN22 ptpn22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN22, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
