Rabbit anti-Human PIG3 Polyclonal Antibody | anti-PIG3 antibody

PIG3 Rabbit Polyclonal

Cat. Num. AAA7602670

• Gene Names: TP53I3; PIG3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PIG3; Polyclonal Antibody; PIG3 Rabbit Polyclonal; anti-PIG3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 322

• Applicable Applications for anti-PIG3 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Tumor protein p53 inducible protein 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602670 (PIG3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 2754812
• NCBI GeneID: 9540
• Molecular Weight: 25,402 Da
• NCBI Official Full Name: Pig3
• NCBI Official Synonym Full Names: tumor protein p53 inducible protein 3
• NCBI Official Symbol: TP53I3
• NCBI Official Synonym Symbols: PIG3
• NCBI Protein Information: quinone oxidoreductase PIG3
• UniProt Protein Name: Quinone oxidoreductase PIG3
• UniProt Gene Name: TP53I3
• UniProt Synonym Gene Names: PIG3
• UniProt Entry Name: QORX_HUMAN

NCBI Description

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Description

TP53I3: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.-.-.-

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytosol

Molecular Function: NADPH:quinone reductase activity; protein homodimerization activity; quinone binding; zinc ion binding

Biological Process: NADP metabolic process; regulation of apoptosis