Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS7600063 (HEPACAM Antibody) at dilution of 1:50)
Rabbit HEPACAM Polyclonal Antibody | anti-HEPACAM antibody
HEPACAM Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS7600063 (HEPACAM Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS7600063 (HEPACAM Antibody) at dilution of 1:50)
Western Blot (WB)
(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7600063 (HEPACAM antibody) at dilution of 1:500)
Western Blot (WB)
(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7600063 (HEPACAM antibody) at dilution of 1:500)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]
Uniprot Description
HEPACAM: Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. Defects in HEPACAM are the cause of leukoencephalopathy megalencephalic with subcortical cysts type 2A (MLC2A). MLC2A is a neurodegenerative disorder characterized by infantile-onset macrocephaly and later onset of motor deterioration, with ataxia and spasticity, seizures, and cognitive decline of variable severity. The brain appears swollen on magnetic resonance imaging with white-matter abnormalities and subcortical cysts, in all stages of the disease. Defects in HEPACAM are the cause of leukoencephalopathy megalencephalic with subcortical cysts type 2B (MLC2B). MLC2B is a neurodegenerative disorder characterized by infantile-onset of macrocephaly and mildly delayed motor development associated with white-matter abnormalities on brain magnetic resonance imaging. The phenotype is milder that MLC2A, with better preserved cerebellar white matter and no subcortical cysts outside the temporal region. On follow-up, patients show normal or almost normal motor function. Some patients have normal intelligence, whereas others have a significant cognitive deficiency. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: axon; cytoplasm; integral to membrane; intercellular junction
Biological Process: cell adhesion; cell cycle arrest; regulation of growth
Disease: Megalencephalic Leukoencephalopathy With Subcortical Cysts 1; Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a; Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation
Research Articles on HEPACAM
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Product Notes
The HEPACAM hepacam (Catalog #AAA7600063) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HEPACAM Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HEPACAM can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the HEPACAM hepacam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HEPACAM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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