NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Description
MGP: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Belongs to the osteocalcin/matrix Gla protein family.
Protein type: Secreted; Secreted, signal peptide; Extracellular matrix
Chromosomal Location of Human Ortholog: 12p12.3
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: protein binding; structural constituent of bone; extracellular matrix structural constituent; calcium ion binding
Biological Process: ossification; cell differentiation; regulation of bone mineralization; cartilage condensation
Disease: Keutel Syndrome
Research Articles on MGP
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Product Notes
The Porcine MGP mgp (Catalog #AAA740783) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA740783 ELISA Kit recognizes Porcine MGP. It is sometimes possible for the material contained within the vial of "Matrix Gla Protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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