Rabbit Transferrin Receptor Protein 2 ELISA Kit | TFR2 elisa kit

Rabbit Transferrin Receptor Protein 2 ELISA Kit

Cat. Num. AAA729750

• Gene Names: TFR2; HFE3; TFRC2
• Reactivity: Rabbit
• Synonyms: Transferrin Receptor Protein 2; Rabbit Transferrin Receptor Protein 2 ELISA Kit; TFR2 elisa kit

• Reactivity: Rabbit

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 5.0-100ng/mL
• Sensitivity: 1.0ng/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Product Categories/Family for TFR2 elisa kit

Cardiovascular

NCBI and Uniprot Product Information

• NCBI GI #: 332309171
• NCBI GeneID: 7036
• NCBI Accession #: NP_001193784.1
• NCBI GenBank Nucleotide #: NM_001206855.1
• Molecular Weight: 86,012 Da
• NCBI Official Full Name: transferrin receptor protein 2 isoform 2
• NCBI Official Synonym Full Names: transferrin receptor 2
• NCBI Official Symbol: TFR2
• NCBI Official Synonym Symbols: HFE3; TFRC2
• NCBI Protein Information: transferrin receptor protein 2
• UniProt Protein Name: Transferrin receptor protein 2
• Protein Family: Transferrin receptor protein
• UniProt Gene Name: TFR2
• UniProt Synonym Gene Names: TfR2
• UniProt Entry Name: TFR2_HUMAN

NCBI Description

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Description

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: integral to plasma membrane; cytoplasm

Molecular Function: transferrin receptor activity

Biological Process: receptor-mediated endocytosis; cellular iron ion homeostasis; iron ion transport

Disease: Hemochromatosis, Type 3