Canine Mitofusin 2 ELISA Kit | MFN2 elisa kit

Canine Mitofusin 2 ELISA Kit

Cat. Num. AAA7262065

• Gene Names: MFN2; HSG; MARF; CMT2A; CPRP1; CMT2A2; HMSN6A; CMT2A2A; CMT2A2B
• Reactivity: Canine
• Synonyms: Mitofusin 2; Canine Mitofusin 2 ELISA Kit; MFN2 elisa kit

• Reactivity: Canine
• Sequence Length: 757

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for MFN2 elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

NCBI and Uniprot Product Information

• NCBI GI #: 16877627
• NCBI GeneID: 9927
• Molecular Weight: 50,041 Da
• NCBI Official Full Name: Mitofusin 2
• NCBI Official Synonym Full Names: mitofusin 2
• NCBI Official Symbol: MFN2
• NCBI Official Synonym Symbols: HSG; MARF; CMT2A; CPRP1; CMT2A2; HMSN6A; CMT2A2A; CMT2A2B
• NCBI Protein Information: mitofusin-2
• UniProt Protein Name: Mitofusin-2
• Protein Family: Mitofusin
• UniProt Gene Name: MFN2
• UniProt Synonym Gene Names: CPRP1; KIAA0214

NCBI Description

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (). Plays an important role in the regulation of vascular smooth muscle cell proliferation (). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions ().