Porcine GDP-Fucose Protein O-Fucosyltransferase 1 (POFUT1) ELISA Kit | POFUT1 elisa kit

Porcine GDP-Fucose Protein O-Fucosyltransferase 1 (POFUT1) ELISA Kit

Cat. Num. AAA7260916

• Gene Names: POFUT1; DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1
• Reactivity: Porcine
• Synonyms: GDP-Fucose Protein O-Fucosyltransferase 1 (POFUT1); Porcine GDP-Fucose Protein O-Fucosyltransferase 1 (POFUT1) ELISA Kit; POFUT1 elisa kit

• Reactivity: Porcine
• Sequence Length: 388

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for POFUT1 elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

Product Categories/Family for POFUT1 elisa kit

Neuroscience; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 27436889
• NCBI GeneID: 23509
• NCBI Accession #: NP_056167.1
• NCBI GenBank Nucleotide #: NM_015352.2
• UniProt Accession #: Q9H488; Q14685; Q5W185; Q9BW76; A8K4R8; E1P5M4
• Molecular Weight: 22,338 Da
• NCBI Official Full Name: GDP-fucose protein O-fucosyltransferase 1 isoform 1
• NCBI Official Synonym Full Names: protein O-fucosyltransferase 1
• NCBI Official Symbol: POFUT1
• NCBI Official Synonym Symbols: DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1
• NCBI Protein Information: GDP-fucose protein O-fucosyltransferase 1
• UniProt Protein Name: GDP-fucose protein O-fucosyltransferase 1
• UniProt Gene Name: POFUT1
• UniProt Synonym Gene Names: FUT12; KIAA0180; O-FucT-1

NCBI Description

This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).