Human Protein phosphatase 1 regulatory subunit 1B (PPP1R1B) ELISA Kit | PPP1R1B elisa kit
Human Protein phosphatase 1 regulatory subunit 1B (PPP1R1B) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DARPP-32: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Cellular Component: cell soma; cytoplasm; nucleus
Molecular Function: type 1 serine/threonine specific protein phosphatase inhibitor activity
Biological Process: negative regulation of female receptivity; transcription, DNA-dependent; response to amphetamine; negative regulation of protein kinase activity; visual learning
Similar Products
Product Notes
The Human PPP1R1B ppp1r1b (Catalog #AAA7245810) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7245810 ELISA Kit recognizes Human PPP1R1B. It is sometimes possible for the material contained within the vial of "Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
