Guinea Pig Glutamate receptor, ionotropic kainate 2 (GRIK2) ELISA Kit | Grik2 elisa kit
Guinea pig Glutamate receptor, ionotropic kainate 2 (GRIK2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GluR6: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6). It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass
Cellular Component: dendrite cytoplasm; kainate selective glutamate receptor complex; integral to plasma membrane; cell; postsynaptic density; dendrite; integral to membrane; terminal button; perikaryon; presynaptic membrane; postsynaptic membrane; cell soma; membrane; axon; plasma membrane; ionotropic glutamate receptor complex; synapse; intracellular; cell junction
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; ubiquitin conjugating enzyme binding; ionotropic glutamate receptor activity; ubiquitin protein ligase binding; ion channel activity; receptor activity; glutamate receptor activity; PDZ domain binding
Biological Process: regulation of synaptic transmission; regulation of long-term neuronal synaptic plasticity; synaptic transmission, glutamatergic; behavioral fear response; generation of action potential; negative regulation of synaptic transmission, glutamatergic; regulation of short-term neuronal synaptic plasticity; signal transduction; regulation of JNK cascade; receptor clustering; positive regulation of synaptic transmission; cellular calcium ion homeostasis; intracellular protein transport; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; regulation of membrane potential; neuron apoptosis; ionotropic glutamate receptor signaling pathway; transport; positive regulation of neuron apoptosis; ion transport; negative regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential
Research Articles on Grik2
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Product Notes
The Guinea Pig Grik2 grik2 (Catalog #AAA7243824) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7243824 ELISA Kit recognizes Guinea Pig Grik2. It is sometimes possible for the material contained within the vial of "Glutamate receptor, ionotropic kainate 2 (GRIK2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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