Human 17 beta hydroxysteroid dehydrogenase type 6 (HSD17B6) ELISA Kit | HSD17B6 elisa kit

Human 17 beta hydroxysteroid dehydrogenase type 6 (HSD17B6) ELISA Kit

Gene Names

HSD17B6; HSE; RODH; SDR9C6

Reactivity

Human

Synonyms

17 beta hydroxysteroid dehydrogenase type 6 (HSD17B6); Human 17 beta hydroxysteroid dehydrogenase type 6 (HSD17B6) ELISA Kit; Human 17 b hydroxysteroid dehydrogenase type 6 (HSD17B6) ELISA Kit; HSD17B6 elisa kit

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Cat. Num. AAA7242152 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Assay Type

Competitive

Detection Range

1.0-25ng/mL

Sensitivity

0.1ng/mL

Preparation and Storage

Store all reagents at 2-8 degree C.

Product Categories/Family for HSD17B6 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

NCBI GI #

19743808

NCBI GeneID

8630

NCBI Accession #

NP_003716.2

NCBI GenBank Nucleotide #

NM_003725.3

Molecular Weight

35,966 Da

NCBI Official Full Name

17-beta-hydroxysteroid dehydrogenase type 6

NCBI Official Synonym Full Names

hydroxysteroid (17-beta) dehydrogenase 6

NCBI Official Symbol

HSD17B6

NCBI Official Synonym Symbols

HSE; RODH; SDR9C6

NCBI Protein Information

17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD 6; oxidoreductase; 3-alpha->beta-HSE; retinol dehydrogenase; 3-hydroxysteroid epimerase; 3-alpha->beta-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 6 homolog; short chain dehydrogenase/reductase family 9C, member 6; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase

UniProt Protein Name

17-beta-hydroxysteroid dehydrogenase type 6

Protein Family

17-beta-hydroxysteroid dehydrogenase

UniProt Gene Name

HSD17B6

UniProt Synonym Gene Names

RODH; 17-beta-HSD 6; 17-beta-HSD6; 3-alpha->beta-HSE

UniProt Entry Name

H17B6_HUMAN

NCBI Description

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]

Uniprot Description

HSD17B6: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Oxidoreductase; EC 1.1.1.239; EC 1.1.1.62; EC 1.1.1.105

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: early endosome membrane; endoplasmic reticulum; intracellular

Molecular Function: estradiol 17-beta-dehydrogenase activity; electron carrier activity; oxidoreductase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; retinol dehydrogenase activity

Biological Process: androgen biosynthetic process; androgen catabolic process

Research Articles on HSD17B6

1. the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower.

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Product Notes

The Human HSD17B6 hsd17b6 (Catalog #AAA7242152) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7242152 ELISA Kit recognizes Human HSD17B6. It is sometimes possible for the material contained within the vial of "17 beta hydroxysteroid dehydrogenase type 6 (HSD17B6), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Human 17 beta hydroxysteroid dehydrogenase type 6 (HSD17B6) ELISA Kit | HSD17B6 elisa kit