Porcine V-type proton ATPase 116 kDa subunit a isoform 1 (ATP6V0A1) ELISA Kit | ATP6V0A1 elisa kit
Porcine V-type proton ATPase 116 kDa subunit a isoform 1 (ATP6V0A1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ATP6V0A1: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle. Belongs to the V-ATPase 116 kDa subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Energy Metabolism - oxidative phosphorylation; Membrane protein, multi-pass; Transporter, ion channel; Motility/polarity/chemotaxis; Membrane protein, integral; Transporter, iron
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: nucleoplasm; Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; melanosome; integral to membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex
Molecular Function: protein binding; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding
Biological Process: vacuolar acidification; interaction with host; ATP synthesis coupled proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport
Research Articles on ATP6V0A1
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Product Notes
The Porcine ATP6V0A1 atp6v0a1 (Catalog #AAA7237130) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7237130 ELISA Kit recognizes Porcine ATP6V0A1. It is sometimes possible for the material contained within the vial of "V-type proton ATPase 116 kDa subunit a isoform 1 (ATP6V0A1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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