Guinea Pig Ras-related protein Rap-1b (RAP1B) ELISA Kit | RAP1B elisa kit
Guinea pig Ras-related protein Rap-1b (RAP1B) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Uniprot Description
RAP1B: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. Belongs to the small GTPase superfamily. Ras family.
Protein type: G protein, monomeric, Ras; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: 12q14
Cellular Component: membrane; plasma membrane; lipid particle; intercellular junction; intracellular; cytosol; lipid raft
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein complex binding
Biological Process: microvillus biogenesis; platelet activation; cell proliferation; negative regulation of calcium ion-dependent exocytosis; metabolic process; blood coagulation; Rap protein signal transduction
Research Articles on RAP1B
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Product Notes
The Guinea Pig RAP1B rap1b (Catalog #AAA7236256) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7236256 ELISA Kit recognizes Guinea Pig RAP1B. It is sometimes possible for the material contained within the vial of "Ras-related protein Rap-1b (RAP1B), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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