Canine Chromodomain-helicase-DNA-binding protein 8 (CHD8) ELISA Kit | CHD8 elisa kit
Canine Chromodomain-helicase-DNA-binding protein 8 (CHD8) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CHD-8: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Helicase; Transcription factor; EC 3.6.4.12
Cellular Component: nucleoplasm; protein complex; nucleus
Molecular Function: DNA-dependent ATPase activity; histone binding; hydrolase activity; p53 binding; beta-catenin binding; nucleotide binding; helicase activity; methylated histone residue binding; protein binding; DNA helicase activity; hydrolase activity, acting on acid anhydrides; DNA binding; chromatin binding; ATP binding
Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; DNA duplex unwinding; regulation of transcription, DNA-dependent; gut development; ATP-dependent chromatin remodeling; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Research Articles on CHD8
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Product Notes
The Canine CHD8 chd8 (Catalog #AAA7230720) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7230720 ELISA Kit recognizes Canine CHD8. It is sometimes possible for the material contained within the vial of "Chromodomain-helicase-DNA-binding protein 8 (CHD8), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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