Bovine Atlastin-1 (ATL1) ELISA Kit | ATL1 elisa kit

Bovine Atlastin-1 (ATL1) ELISA Kit

Cat. Num. AAA7230715

• Gene Names: ATL1; FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
• Reactivity: Bovine
• Synonyms: Atlastin-1 (ATL1); Bovine Atlastin-1 (ATL1) ELISA Kit; ATL1 elisa kit

• Reactivity: Bovine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for ATL1 elisa kit

Neurobiology

NCBI and Uniprot Product Information

• NCBI GI #: 189181742
• NCBI GeneID: 51062
• NCBI Accession #: NP_001121185.1
• NCBI GenBank Nucleotide #: NM_001127713.1
• Molecular Weight: 63,055 Da
• NCBI Official Full Name: atlastin-1 isoform b
• NCBI Official Synonym Full Names: atlastin GTPase 1
• NCBI Official Symbol: ATL1
• NCBI Official Synonym Symbols: FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
• NCBI Protein Information: atlastin-1; GBP-3; hGBP3; GTP-binding protein 3; guanylate-binding protein 3; spastic paraplegia 3 protein A; brain-specific GTP-binding protein; guanine nucleotide-binding protein 3
• UniProt Protein Name: Atlastin-1
• Protein Family: Atlastin
• UniProt Gene Name: ATL1
• UniProt Synonym Gene Names: GBP3; SPG3A; GBP-3; hGBP3
• UniProt Entry Name: ATLA1_HUMAN

NCBI Description

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

atlastin: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3); also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in ATL1 are the cause of hereditary sensory neuropathy type 1D (HSN1D). HSN1D is a disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Belongs to the GBP family. Atlastin subfamily.

Protein type: EC 3.6.5.-; Membrane protein, multi-pass; Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; axon; endoplasmic reticulum; integral to membrane; Golgi cis cisterna

Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding

Biological Process: endoplasmic reticulum organization and biogenesis; axonogenesis; metabolic process; protein homooligomerization

Disease: Neuropathy, Hereditary Sensory, Type Id; Spastic Paraplegia 3, Autosomal Dominant