Goat Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1) ELISA Kit | NDST1 elisa kit

Goat Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1) ELISA Kit

Cat. Num. AAA7223972

• Gene Names: NDST1; HSST; NST1
• Reactivity: Goat
• Synonyms: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1); Goat Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1) ELISA Kit; NDST1 elisa kit

• Reactivity: Goat

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for NDST1 elisa kit

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 4505351
• NCBI GeneID: 3340
• NCBI Accession #: NP_001534.1
• NCBI GenBank Nucleotide #: NM_001543.4
• Molecular Weight: 62,065 Da
• NCBI Official Full Name: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
• NCBI Official Synonym Full Names: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
• NCBI Official Symbol: NDST1
• NCBI Official Synonym Symbols: HSST; NST1
• NCBI Protein Information: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; [Heparan sulfate]-glucosamine N-sulfotransferase 1
• UniProt Protein Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
• UniProt Gene Name: NDST1
• UniProt Synonym Gene Names: HSST; HSST1; NDST-1; N-HSST 1; HSNST 1
• UniProt Entry Name: NDST1_HUMAN

NCBI Description

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Description

NDST1: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.8.2.8; Hydrolase

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity

Biological Process: smoothened signaling pathway; fibroblast growth factor receptor signaling pathway; glycosaminoglycan metabolic process; MAPKKK cascade; pathogenesis; respiratory gaseous exchange; embryonic viscerocranium morphogenesis; glycosaminoglycan biosynthetic process; polysaccharide biosynthetic process; heparin biosynthetic process; forebrain development; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; midbrain development; embryonic neurocranium morphogenesis; inflammatory response

Disease: Mental Retardation, Autosomal Recessive 46