Bovine Structural maintenance of chromosomes protein 5 (SMC5) ELISA Kit | SMC5 elisa kit
Bovine Structural maintenance of chromosomes protein 5 (SMC5) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SMC5: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. Belongs to the SMC family. SMC5 subfamily.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 9q21.12
Cellular Component: nucleoplasm; PML body; chromosome, telomeric region; nucleus; cell junction
Molecular Function: protein binding; ATP binding
Biological Process: mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; cell division; telomere maintenance via recombination; positive regulation of mitotic metaphase/anaphase transition; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining
Research Articles on SMC5
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Product Notes
The Bovine SMC5 smc5 (Catalog #AAA7214527) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7214527 ELISA Kit recognizes Bovine SMC5. It is sometimes possible for the material contained within the vial of "Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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