Rat Nucleoside diphosphate kinase B (NME2) ELISA Kit | NME2 elisa kit

Rat Nucleoside diphosphate kinase B (NME2) ELISA Kit

Cat. Num. AAA7212020

• Gene Names: NME2; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
• Reactivity: Rat
• Synonyms: Nucleoside diphosphate kinase B (NME2); Rat Nucleoside diphosphate kinase B (NME2) ELISA Kit; NME2 elisa kit

• Reactivity: Rat

• Samples: Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
• Sensitivity: 0.1 ng/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for NME2 elisa kit

Intended Uses: This NME2 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Rat NME2. This ELISA kit for research use only!

NCBI and Uniprot Product Information

• NCBI GI #: 66392227
• NCBI GeneID: 4831
• NCBI Accession #: NP_001018149.1
• NCBI GenBank Nucleotide #: NM_001018139.2
• Molecular Weight: 30,137 Da
• NCBI Official Full Name: nucleoside diphosphate kinase B isoform a
• NCBI Official Synonym Full Names: NME/NM23 nucleoside diphosphate kinase 2
• NCBI Official Symbol: NME2
• NCBI Official Synonym Symbols: PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
• NCBI Protein Information: nucleoside diphosphate kinase B; HEL-S-155an; NDP kinase B; c-myc transcription factor; histidine protein kinase NDKB; nucleotide diphosphate kinase B; c-myc purine-binding transcription factor PUF; epididymis secretory sperm binding protein Li 155an; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in
• UniProt Protein Name: Nucleoside diphosphate kinase B
• UniProt Gene Name: NME2
• UniProt Synonym Gene Names: NM23B; NDK B; NDP kinase B
• UniProt Entry Name: NDKB_HUMAN

NCBI Description

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

Uniprot Description

NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, nucleoside diphosphate; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Kinase, other; EC 2.7.13.3; EC 2.7.4.6; Nucleotide Metabolism - pyrimidine; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: ruffle; centrosome; focal adhesion; membrane; mitochondrion; perinuclear region of cytoplasm; lamellipodium; cytoplasm; intermediate filament; nucleus; cytosol

Molecular Function: protein binding; gamma-tubulin binding; protein histidine kinase activity; metal ion binding; nucleoside diphosphate kinase activity; intermediate filament binding; protein kinase binding; transcription factor activity; single-stranded DNA binding; ATP binding

Biological Process: integrin-mediated signaling pathway; GTP biosynthetic process; peptidyl-histidine phosphorylation; response to cAMP; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; UTP biosynthetic process; negative regulation of myeloid leukocyte differentiation; hippocampus development; nucleoside diphosphate phosphorylation; response to testosterone stimulus; CTP biosynthetic process; regulation of transcription, DNA-dependent; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; cell adhesion; positive regulation of epithelial cell proliferation; regulation of epidermis development; purine nucleotide metabolic process; negative regulation of apoptosis; positive regulation of keratinocyte differentiation; response to amine stimulus