Guinea Pig Heterogeneous nuclear ribonucleoprotein L-like (HNRPLL) ELISA Kit | HNRNPLL elisa kit
Guinea pig Heterogeneous nuclear ribonucleoprotein L-like (HNRPLL) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Uniprot Description
HNRPLL: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component: membrane; ribonucleoprotein complex; nucleus
Molecular Function: mRNA binding; protein binding; nucleotide binding
Biological Process: mRNA processing; positive regulation of RNA splicing
Research Articles on HNRNPLL
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Product Notes
The Guinea Pig HNRNPLL hnrnpll (Catalog #AAA7207228) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7207228 ELISA Kit recognizes Guinea Pig HNRNPLL. It is sometimes possible for the material contained within the vial of "Heterogeneous nuclear ribonucleoprotein L-like (HNRPLL), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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