Mouse F-box only protein 31 (FBXO31) ELISA Kit | FBXO31 elisa kit

Mouse F-box only protein 31 (FBXO31) ELISA Kit

Cat. Num. AAA7204732

• Gene Names: FBXO31; FBX14; Fbx31; MRT45; FBXO14; pp2386
• Reactivity: Mouse
• Synonyms: F-box only protein 31 (FBXO31); Mouse F-box only protein 31 (FBXO31) ELISA Kit; FBXO31 elisa kit

• Reactivity: Mouse

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 0.5-10ng/mL
• Sensitivity: 0.1ng/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for FBXO31 elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 83035136
• NCBI GeneID: 79791
• NCBI Accession #: NP_079011.3
• NCBI GenBank Nucleotide #: NM_024735.4
• Molecular Weight: 49,039 Da
• NCBI Official Full Name: F-box only protein 31 isoform 1
• NCBI Official Synonym Full Names: F-box protein 31
• NCBI Official Symbol: FBXO31
• NCBI Official Synonym Symbols: FBX14; Fbx31; MRT45; FBXO14; pp2386
• NCBI Protein Information: F-box only protein 31; SCF ubiquitin ligase specificity factor; putative breast cancer tumor-suppressor
• UniProt Protein Name: F-box only protein 31
• Protein Family: F-box only protein
• UniProt Gene Name: FBXO31
• UniProt Synonym Gene Names: FBX14; FBX31; PP2386
• UniProt Entry Name: FBX31_HUMAN

NCBI Description

This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: cell soma; SCF ubiquitin ligase complex

Molecular Function: cyclin binding

Biological Process: cyclin catabolic process; G1 DNA damage checkpoint; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus

Disease: Mental Retardation, Autosomal Recessive 45