Sorting nexin-3 Recombinant Protein | SNX3 recombinant protein

Recombinant human Sorting nexin-3

Cat. Num. AAA717240

• Gene Names: SNX3; SDP3; Grd19; MCOPS8
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sorting nexin-3; Recombinant human Sorting nexin-3; Recombinant human Sorting nexin-3 protein; SNX3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence: ETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

• Preparation and Storage: Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.

SDS-PAGE

Related Product Information for SNX3 recombinant protein

Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G By similarity. Not involved in EGFR degradation.

References

[1] "Identification of a family of sorting nexin molecules and characterization of their association with receptors."

NCBI and Uniprot Product Information

• NCBI GI #: 222418635
• NCBI GeneID: 8724
• NCBI Accession #: NP_003786.1
• NCBI GenBank Nucleotide #: NM_003795.4
• UniProt Accession #: O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45; A8K0B1; E1P5E4; E1P5E5
• Molecular Weight: 44 KD
• NCBI Official Full Name: Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: sorting nexin 3
• NCBI Official Symbol: SNX3
• NCBI Official Synonym Symbols: SDP3; Grd19; MCOPS8
• NCBI Protein Information: sorting nexin-3; sorting nexin 3A
• UniProt Protein Name: Sorting nexin-3
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX3
• UniProt Entry Name: SNX3_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G

By similarity. Not involved in EGFR degradation. Ref.2 Ref.14

Subunit structure: Interacts with USP10 and SCNN1A

By similarity.

Subcellular location: Early endosome Ref.2.

Domain: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Ref.2

Post-translational modification: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10

By similarity.

Involvement in disease: A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8) [

MIM:601349]. Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. Ref.13

Sequence similarities: Belongs to the sorting nexin family.Contains 1 PX (phox homology) domain.