Sorting nexin-3 Recombinant Protein | SNX3 recombinant protein

Recombinant Human Sorting nexin-3

Cat. Num. AAA954825

• Gene Names: SNX3; SDP3; Grd19; MCOPS8
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sorting nexin-3; Recombinant Human Sorting nexin-3; Protein SDP3; SNX3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 3-162aa; Full Length
• Sequence: ETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
• Sequence Length: 140

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for SNX3 recombinant protein

Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs.

Product Categories/Family for SNX3 recombinant protein

Transport

References

Identification of a family of sorting nexin molecules and characterization of their association with receptors.Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I.Mol. Cell. Biol. 18:7278-7287(1998)

NCBI and Uniprot Product Information

• NCBI GI #: 665505924
• NCBI GeneID: 8724
• NCBI Accession #: NP_001287858.1
• NCBI GenBank Nucleotide #: NM_001300929.1
• UniProt Accession #: O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45; A8K0B1; E1P5E4; E1P5E5
• Molecular Weight: 45.6 kDa
• NCBI Official Full Name: sorting nexin-3 isoform d
• NCBI Official Synonym Full Names: sorting nexin 3
• NCBI Official Symbol: SNX3
• NCBI Official Synonym Symbols: SDP3; Grd19; MCOPS8
• NCBI Protein Information: sorting nexin-3
• UniProt Protein Name: Sorting nexin-3
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX3
• UniProt Entry Name: SNX3_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

SNX3: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8). Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: clathrin-coated vesicle; cytoplasm; cytosol; early endosome; early endosome membrane; endosome membrane; extrinsic to membrane; retromer complex

Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; protein phosphatase binding

Biological Process: endocytosis; hemoglobin biosynthetic process; membrane invagination; negative regulation of phagocytosis; negative regulation of protein catabolic process; negative regulation of protein transport; negative regulation of virion penetration into host cell; protein to membrane docking; regulation of cellular protein metabolic process; regulation of intracellular protein transport; regulation of Wnt receptor signaling pathway; response to bacterium; transferrin transport

Disease: Microphthalmia, Syndromic 8